When traditional antidepressants don’t help, many people turn to alternative mental health treatment options like TMS therapy or ketamine therapy. Both treatments are FDA-approved and growing in popularity, especially for people struggling with treatment-resistant depression. But how do you know which one is right for you? Below, we break down the key differences, benefits, and considerations to help you compare TMS vs. ketamine therapy.
Comparing TMS and Ketamine: Pros, Cons, and Results for Depression
TMS (Transcranial Magnetic Stimulation) uses magnetic pulses to stimulate areas of the brain involved in mood control. It’s non-invasive and done while you’re awake and alert.
Ketamine therapy, often delivered through an IV infusion or nasal spray, uses a low dose of the psychedelic anesthetic ketamine. It alters brain chemistry quickly, sometimes within hours.
Here’s how the two compare:
- Treatment process
- TMS therapy is typically done five days a week for 4 to 6 weeks.
- Ketamine therapy is often done twice a week over several weeks, with booster sessions as needed.
- TMS therapy is typically done five days a week for 4 to 6 weeks.
- Onset of results
- Ketamine often provides fast relief—sometimes after just one session.
- TMS builds gradually but provides long-term benefits with fewer side effects for many patients.
- Ketamine often provides fast relief—sometimes after just one session.
- Side effects
- TMS therapy may cause mild scalp discomfort or headache.
- Ketamine therapy can lead to nausea, dizziness, and dissociation (feeling disconnected from your body or reality).
- TMS therapy may cause mild scalp discomfort or headache.
- Safety and monitoring
- TMS has no sedating effects, and patients can drive home after sessions.
- Ketamine requires monitoring during and after the session, and you’ll need a ride home.
- TMS has no sedating effects, and patients can drive home after sessions.
- Long-term benefits
- TMS is often used for long-term depression management with sustained results over months or years.
- Ketamine may require regular boosters, and some patients may build tolerance.
- TMS is often used for long-term depression management with sustained results over months or years.
Is TMS Better Than Ketamine for Depression? What the Research Says
Research shows both treatments are effective for people with treatment-resistant depression. But they work in different ways. TMS targets brain function through magnetic stimulation. Ketamine affects brain chemistry through NMDA receptor blocking. Neither is “better” in all cases—it depends on the individual.
“Both TMS and ketamine offer new hope when medications and talk therapy fall short,” says Dr. Clayton L. Allison, M.D., psychiatrist at NorTex Psychiatry. “TMS is a great choice for long-term relief with minimal side effects. Ketamine can provide fast-acting relief but often works best as part of a broader treatment plan.”
Choosing Between TMS and Ketamine for Depression Relief
Here are questions to ask when deciding:
- Do I want a non-medication option?
→ TMS therapy is drug-free and doesn’t affect your thinking or consciousness. - Am I looking for fast relief from severe symptoms?
→ Ketamine therapy may be a good fit if you’re struggling with suicidal thoughts or severe depression that needs urgent support. - Do I have time for daily appointments?
→ TMS requires a regular schedule, while ketamine offers more flexibility.
“We help patients decide based on their goals, lifestyle, and medical history,” says Brittany Huckaby, PHNP. “Some choose TMS for its long-term safety. Others try ketamine first to get rapid relief, then consider TMS for ongoing care.”
TMS vs. Psychedelic Therapy: A Deep Dive into Modern Mental Health Solutions
TMS is often preferred by those who want to avoid mind-altering experiences. Ketamine, while not considered a classic psychedelic, is part of the larger psychedelic therapy trend in mental health care. Both are effective alternatives to traditional depression treatment, but they serve different needs.
TMS vs. Ketamine for Depression: Cost, Duration, and Results Explained
- TMS is often covered by insurance if you’ve tried other treatments first.
- Ketamine therapy is usually self-pay, though some clinics offer payment plans.
- TMS takes longer but may require fewer sessions in the long run.
- Ketamine works fast but may need repeat treatments to maintain results.
Are TMS and Ketamine Effective Alternatives to Traditional Depression Treatment?
Yes. Both therapies are changing lives—especially for people who have tried multiple medications without success. They represent the next wave of alternative mental health treatment options, helping people feel better without relying solely on pills.
TMS or Ketamine? How to Choose the Right Therapy for Your Mental Health
If you’re still unsure, talk to a mental health provider trained in both treatments. At NorTex Psychiatry, we offer TMS therapy for depression near Allen, McKinney, Frisco, and Dallas and can refer you to trusted ketamine depression treatment clinics if appropriate.
Breaking Down TMS and Ketamine Therapy: Which Alternative Treatment Fits You?
- Prefer drug-free, non-invasive care? → Book a TMS consultation.
- Need fast relief for urgent depression symptoms? → Schedule a ketamine therapy session.
- Interested in a long-term plan to feel like yourself again? → Let’s compare your options and help you find the right fit.
Ready to take the next step?
Contact NorTex Psychiatry today to book a TMS consultation, compare TMS and ketamine therapy, and find the best path forward.
We’re here to help you feel better—with care that’s compassionate, effective, and personalized to your needs.
